Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study

Rocznik Ochrona Środowiska 2023, vol. 25, pp. 265-273

Ayper Boga Pekmezekmek1 This email address is being protected from spambots. You need JavaScript enabled to view it.orcid, peopleMustafa Emre1 orcid, peopleErdal Tunç2 orcid, peopleYasar Sertdemir1 orcid

institution 1. Cukurova University, Türkiye
2. Artuklu University, Türkiye
mail author This email address is being protected from spambots. You need JavaScript enabled to view it.
doi1 https://doi.org/10.54740/ros.2023.028
download pdfdownload docxpprocedure
abstract

It is well documented that nicotine causes low birth weight, preterm birth, pregnancy difficulties, lower fertility, inhibition of spermatogenesis, and decreased steroidogenesis and potassium channels conductance of Xenopus oocytes. Lung cancer is the most well-known adverse impact of nicotine. This work used a 96-hour FETAX test to examine how concurrent administration of glucose monohydrate modifies the effects of exposure to nicotine, nicotine sulfate, and/or glucose on ion channels and membrane potential in Xenopus leavis embryos at an early stage of development. In-vitro fertilised embryos were treated with nicotine and glucose alone or in combination for this aim, and the effects of those treatments were then assessed for potential teratogenic effects. At the conclusion of the FETAX technique, the ratios of healthy, abnormal, and dead embryos were calculated, and the length of embryos in each treatment group was assessed. The ratios of abnormal and dead embryos were considerably higher with nicotine treatment alone compared to controls. Compared to the results of the nicotine-alone treatment group, the ratio of aberrant embryos was marginally reduced by concurrent glucose and nicotine therapy. In contrast, the ratio of normal embryos was raised. Additionally, treatments with glucose, nicotine, and Nic+Glu significantly altered the resting membrane potentials of fertilised oocytes (p < 0.001). Our findings indicated that the simultaneous treatment groups that also received glucose had a protective impact on embryos. Such structured, more sophisticated research is required to confirm these findings.

 keywords


D(+) glucose monohydrate, embryo-teratogenicity, FETAX, nicotine sulfate, Xenopus laevis

fulltext

 

share

AMA Style
Boga Pekmezekmek A, Emre M, Tunç E, Sertdemir Y. Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study. Rocznik Ochrona Środowiska. 2023; 25. https://doi.org/10.54740/ros.2023.028

ACM Style
Boga Pekmezekmek, A., Emre, M., Tunç, E., Sertdemir, Y. 2023. Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study. Rocznik Ochrona Środowiska. 25. DOI:https://doi.org/10.54740/ros.2023.028

ACS Style
Boga Pekmezekmek, A.; Emre, M.; Tunç, E.; Sertdemir, Y. Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study Rocznik Ochrona Środowiska 2023, 25, 265-273. https://doi.org/10.54740/ros.2023.028

APA Style
Boga Pekmezekmek, A., Emre, M., Tunç, E., Sertdemir, Y. (2023). Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study. Rocznik Ochrona Środowiska, 25, 265-273. https://doi.org/10.54740/ros.2023.028

ABNT Style
BOGA PEKMEZEKMEK, A.; EMRE, M.; TUNÇ, E.; SERTDEMIR, Y. Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study. Rocznik Ochrona Środowiska, v. 25, p. 265-273, 2023. https://doi.org/10.54740/ros.2023.028

Chicago Style
Boga Pekmezekmek, Ayper, Emre, Mustafa, Tunç, Erdal, Sertdemir, Yasar. 2023. "Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study". Rocznik Ochrona Środowiska 25, 265-273. https://doi.org/10.54740/ros.2023.028

Harvard Style
Boga Pekmezekmek, A., Emre, M., Tunç, E., Sertdemir, Y. (2023) "Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study", Rocznik Ochrona Środowiska, 25, pp. 265-273. doi:https://doi.org/10.54740/ros.2023.028

IEEE Style
A. Boga Pekmezekmek, M. Emre, E. Tunç, Y. Sertdemir, "Ameloriate Effect of Glucose Monohydrate on Nicotine Sulfate-induced Toxicity and Teratogenicity in Xenopus embryos: an Experimental Study", RoczOchrSrod, vol 25, pp. 265-273. https://doi.org/10.54740/ros.2023.028

Popular in 2023